Santosh Kumar Jha

Santosh Kumar Jha, Ph.D.

Click here to edit subtitle

                                                                                   Google Citation

Publications:

Acharya N*, Mishra P*, Jha SK (2016) Evidence for Dry Molten Globule-Like Domains in the pH-Induced Equilibrium Folding Intermediate of a Multi-Domain Protein, J. Phys. Chem. Lett., 7:173 - 179. * indicates joint first author.

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Jha SK, Marqusee S (2014) Kinetic evidence for a two-stage mechanism of protein denaturation by guanidinium chloride. Proc. Natl. Acad. Sci. USA, 111:4856-4861. (Recommended by Faculty of 1000 Biology http://f1000.com/prime/718313266)

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Jha SK*, Ji M*, Gaffney KJ, Boxer SG (2012) Site-specific measurement of water dynamics in the substrate pocket of ketosteroid isomerase  using time-resolved vibrational spectroscopy. J. Phys. Chem. B., 116:11414-11421. * indicates joint first author.

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------


--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Jha SK*, Ji M*, Gaffney KJ, Boxer SG (2011) Direct measurement of the protein response to an electrostatic perturbation that mimics the catalytic cycle in ketosteroid isomerase. Proc. Natl. Acad. Sci. USA., 108:16612-16617. * indicates joint first author.

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Jha SK, Dasgupta A, Malhotra P, Udgaonkar JB (2010) Identification of multiple folding pathways of monellin using pulsed thiol labeling and mass  spectrometryBiochemistry, 50:3062-3074.

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Jha SK, Udgaonkar JB (2009) Direct evidence for a dry molten globule intermediate during the unfolding of a small protein. Proc. Natl. Acad. Sci. USA., 106:12289-12294. (Recommended by Faculty of 1000 Biology http://f1000.com/14021991)

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Jha SK, Dhar D, Krishnamoorthy G, Udgaonkar JB (2009) Continuous dissolution of structure during the unfolding of a small protein. Proc. Natl. Acad. Sci. USA., 106:11113-11118.

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------


================================================================================================================

Review articles:

Jha SK, Udgaonkar JB (2010) Free energy barriers in protein folding and unfolding reactions. Curr. Sci., 99:457-475.

================================================================================================================

Miscellaneous:

Written a popular science article in the Hindi language daily newspaper ‘Prabhat Khabar’. Naye jeevan ki khoj (Discovery of a new life), December 12, 2010.